Up to 23 August 2022, 53 million people received a first dose of COVID-19 vaccine, 50 million received a second dose and 40 million received a third or booster dose. Three COVID-19 vaccines - the monovalent COVID-19 Vaccine Pfizer/BioNTech, COVID-19 Vaccine AstraZeneca and monovalent COVID-19 Vaccine Moderna – were used in the primary and booster vaccination campaigns up to the end of August 2022. A national immunisation campaign has been underway since early December 2020. Vaccination is the single most effective way to reduce deaths and severe illness from COVID-19. Over the course of the pandemic over 178,407 people across the UK have died within 28 days of a positive test for coronavirus (COVID-19). Any new assessments or safety issues regarding vaccines used in the primary and initial booster campaigns will also be included in this record, however previous and known information on these vaccines will remain available as a record only and can be viewed on the government website. Since January 2023, the MHRA revised the format of the Summary of Yellow Card reporting to focus on the COVID-19 vaccines administered from the beginning of the Autumn 2022 booster campaign. We would ask anyone who suspects they have experienced a side effect linked with their COVID-19 vaccine to report via the Yellow Card website. Additionally, monthly updates of Adverse Drug Reaction (ADR) data will continue with the new interactive COVID-19 vaccine reports. Robust safety monitoring and surveillance of any COVID-19 vaccines used in the UK will continue along with timely communication on any updated safety advice when needed. This report is therefore the last regular publication of the Summary of Yellow Card reporting for COVID-19 vaccines. The Commission on Human Medicine (CHM) has advised that given the end of the Autumn 2022 booster campaign and the stable safety profile of the COVID-19 vaccines, the MHRA should transition to routine data publication and communication of safety concerns for COVID-19 vaccines.
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